Beginning this morning, there will be single-lane closures on U.S. Route 40 near Elm Grove between 7 a.m. and 5 p.m.
Closures are expected to continue for two weeks.
The Fort Henry Bridge will also experience some closures this week.
Between 11 p.m. and 5 a.m., the bridge will be closed in both directions for rehabilitation work. Crews will be setting up cranes and removing steel beams.
Officials also say there will be intermittent lane closures on Ohio Route 7 during the same time frame.